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Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia

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Thus, the in vitro and in vivo anti-tumor activities of lintuzumab SGN , a humanized monoclonal anti-CD33 antibody undergoing clinical evaluation, were investigated. In vitro assays were used to assess the ability of lintuzumab to mediate effector functions and to decrease the production of growth factors from AML cells. Survival of the mice was dependent upon the activity of resident macrophages and neutrophils. The results suggest that lintuzumab may exert its therapeutic effects by modulating the cytokine milieu in the tumor microenvironment and through effector mediated cell killing. Given that lintuzumab induced meaningful responses in a phase 1 clinical trial, the preclinical antitumor activities defined in this study may underlie its observed therapeutic efficacy in AML patients.
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I reached my hand under the sheet and touched my pussy. I was so wet. I raised my hips and pulled my gown to my waist, then sat up and eased it over my head pulling it off.

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