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Revenge porn is the distribution of sexually explicit images or video of individuals without their permission. The possession of the material may be used by the perpetrators to blackmail the subjects into performing other sex acts, to coerce them into continuing the relationship, to punish them for ending the relationship, or to silence them. In the wake of civil lawsuits and the increasing numbers of reported incidents, legislation has been passed in a number of countries and jurisdictions to outlaw the practice, though approaches have varied. The practice has also been described as a form of psychological abuse and domestic violence , as well as a form of sexual abuse. The term "revenge porn" generally refers to the uploading of this sexually explicit material to humiliate and intimidate the subject, who has broken off the relationship. Given the practice by some companies of searching for potential sources of bad publicity, many victims of revenge porn have lost their jobs and found themselves effectively unhirable.
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06.06.2019
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Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia

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Thus, the in vitro and in vivo anti-tumor activities of lintuzumab SGN , a humanized monoclonal anti-CD33 antibody undergoing clinical evaluation, were investigated. In vitro assays were used to assess the ability of lintuzumab to mediate effector functions and to decrease the production of growth factors from AML cells. Survival of the mice was dependent upon the activity of resident macrophages and neutrophils. The results suggest that lintuzumab may exert its therapeutic effects by modulating the cytokine milieu in the tumor microenvironment and through effector mediated cell killing. Given that lintuzumab induced meaningful responses in a phase 1 clinical trial, the preclinical antitumor activities defined in this study may underlie its observed therapeutic efficacy in AML patients.
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